RGNCY-0007 (BMS819881, MCHR1 antagonist)
BMS-819881 is a MCHR1 (Melanin Concentrating Hormone Receptor 1) antagonist with minimal hERG activity, with potential as an anti-obesity drug. Currently in Phase 1 clinical trial as the phosphate ester pro-drug.
Systematic Name: R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Molecular Weight: 468.95
Reference: Washburn, William N., et al. "Identification of a non-basic melanin hormone receptor 1 antagonist as an anti-obesity clinical candidate." Journal of Medicinal Chemistry 57.18 (2014): 7509–7522.
Interested in this reagent? E-mail us at firstname.lastname@example.org and let us know.
Tags: RGNCY-0007, BMS819881, MCHR1, Melanin