RGNCY-0015 (CPD5 - MPS-TTK Inhibitor)

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RGNCY-0015 is a protein kinase inhibitor with activity against MPS1/TTK. It has an IC50 of 0.10 µM in cellular proliferation inhibition assay using A2780 cells.



Systematic Name: N-(2,6-diethylphenyl)-8-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

SMILES: COC1=CC(N2CCN(C)CC2)=CC=C1NC3=NC=C(CCC4=C5N(C)N=C4C(NC6=C(CC)C=CC=C6CC)=O)C5=N3

Molecular Weight:
580.74

Formula: C33H40N8O2

PMID: 21723120


Reference: Caldarelli, Marina, et al. "Synthesis and SAR of new pyrazolo [4,3-] quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors." Bioorganic & Medicinal Chemistry Letters 21.15 (2011): 4507-4511.


Data Sheet

MSDS


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Tags: TTK, RGNCY-0015, CPD5, MPS, A2780