RGNCY-0015 (CPD5 - MPS-TTK Inhibitor)
RGNCY-0015 is a protein kinase inhibitor with activity against MPS1/TTK. It has an IC50 of 0.10 µM in cellular proliferation inhibition assay using A2780 cells.
Systematic Name: N-(2,6-diethylphenyl)-8-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Molecular Weight: 580.74
Reference: Caldarelli, Marina, et al. "Synthesis and SAR of new pyrazolo [4,3-] quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors." Bioorganic & Medicinal Chemistry Letters 21.15 (2011): 4507-4511.
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Tags: TTK, RGNCY-0015, CPD5, MPS, A2780