RGNCY-0022 (CCT196969, pan RAF/SFK inhibitor)
SMILES: CC(C)C)C1=NN(C2=CC=CC=C2)C(NC(NC(C(F)=C3)
=CC=C3OC4=C5C(NC(C=N5)=O)=NC=C4)=O)=C1
Formula: C27H24FN7O3
Systematic Name: 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
Molecular Weight: 513.53
PubMed Ref.: 25500121
Reference: Girotti, Maria Romina, et al. "Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma." Cancer Cell 27.1 (2015): 85-96.
Reference: Girotti, Maria Romina, et al. "Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma." Cancer Cell 27.1 (2015): 85-96.
Tags: Cancer, Kinase, Melanoma, Src, SFK, RAF, Tumor, RGNCY-0022, CCT196969, BRAF, NRAS, MEK