is a novel analog of ceramide that inhibits ATP-dependent transport of
ceramide from the endoplasmic reticulum to the site of sphingomyelin
synthesis as demonstrated in Chinese hamster ovary cells. This occurs
without the inhibition of protein trafficking, thereby inhibiting
conversion of ceramide to sphingomyelin, but not to glucosylceramide, in
cells. HPA-12 is a possible prodrug for the development of a family of
inhibitors of ceramide trafficking.
Systematic Name: N-((2R,4S)-1,4-dihydroxy-4-phenylbutan-2-yl)dodecanamide
Chemical Formula: C22H37NO3
Molecular Weight: 363.54
Reference: Yasuda, Satoshi, et al. "A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis." Journal of Biological Chemistry 276.47 (2001): 43994-44002.
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Tags: ceramide, sphingomyelin, RGNCY-0024, HPA-12, HPA