RGNCY-0047 (HYPOX-3 Hypoxia probe )
HYPOX-3 is an activatable molecular imaging probe to detect hypoxia in mouse models of retinal vascular diseases. It is a near-infrared (NIR) imaging agent coupled to a dark quencher, Black Hole Quencher 3 (BHQ3), which contains a hypoxia-sensitive cleavable azo-bond. HYPOX-3 was cleaved in hypoxic retinal cell culture and animal models. This enabled detection of hypoxia with high selectivity and sensitivity without acute toxicity and undetectable fluorescence under normoxia.
Systematic Name: 4-(2-((1E,3E)-5-((E)-5-(2-((3-((4-((E)-(7-(diethylamino)-5-phenylphenazin-5-ium-3-yl)diazenyl)phenyl)(methyl)amino)propyl)amino)-2-oxoethyl)-1-ethyl-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate chloride
Reference: Uddin MI, Evans, SM et al. Applications of Azo-based probes for imaging retinal hypoxia. Med Chem Letters (2015), 6:445-449.
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Tags: hypoxia, imaging, retina, RGNCY-0047, HYPOX, HYPOX-3, Vascular, Fluorescence