RGNCY-0060 (MS0 NAMPT inhibitor)
NAMPT (nicotinamide phosphoribosyltransferase) is a promising therapeutic target for cancer. MS0 is a novel NAMPT inhibitor with excellent in vitro activity (IC50 = 9.87 + 1.15 nM) and anti-proliferative activity against multiple human cancer cell lines (HepG2, A549, ad HCT116) and stem-like cancer cells. MS0 specifically binds to the NAMPT target in living cells. MS0 is a useful tool in developing NAMPT inhibitors as anti-cancer therapeutic agents.
Systematic Name: N-(4-(piperidin-1-ylsulfonyl)phenyl)-N'-(pyridin-3-ylmethyl)ethene-1,1-diamine
Mol Wt: 372.49
Tags: NAMPT, Cancer, small molecule, Tumor, MS0, MSo, RGNCY-0060