RGNCY-0077 (1a PPARϒ agonist PPARδ anatgonist)
Compound 1a significantly increases adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs) which is associated with improved insulin sensitivity. The adiponectin-promoting activity of 1a significantly correlates with its binding activity to both peroxisome proliferator activated receptor (PPAR) ϒ and PPARδ. It is both a partial PPARϒ agonist and PPARδ anatgonist. In the diabetic mouse (STZ induced) model, orally administered 1a significantly decreases glucose and triglyceride serum levels, supporting its anti-diabetic potential.
Systematic Name: (2S,3R,4S,5R)-3,4-dihydroxy-5-(6-(3-iodophenethyl)-9H-purin-9-yl)-N-methyltetrahydrofuran-2-carboxamide
Molecular Weight: 509.30
Tags: Diabetes, PPAR, RGNCY-0077, 1a, anti-diabetic, PPAR alpha, PPAR delta, adiponectin, insulin