RGNCY-0124 (Compound 12 HPV E6-p53 inhibitor)

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Compound 12 is an inhibitor of E6-mediated degradation of p53 through the disruption of E6-p53 binding in vitro and in human papillomavirus (HPV) cells.  HPV-E6 oncoprotein promoted p53 degradation is linked to tumor progression.  Compound 12 could restore p53 intracellular levels and transcriptional activity, reduce viability and proliferation of HPV-positive cancer cell and block 3D cervosphere formation.  Compound 12 exerts antitumor activity by inducing cell cycle arrest and senescence.  Compound 12 presents a new approach for anti-HPV drug development.



Systematic Name: 2-((4-fluorophenyl)amino)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)pyrimidin-4(3H)-one

SMILES: FC1=CC=C(NC2=NC(CSC3=NN=NN3C4=CC=CC=C4)=CC(N2)=O)C=C1

Formula:  C18H14FN7OS

Mol Wt: 395.42




Tags: Cancer, p53, RGNCY-0124, Compound 12, HPV, HPV-E6, human papillomavirus, E6-p53