RGNCY-0123 (FCY-302 Apoptosis inducer)
FCY-302 is a novel inducer of apoptosis in leukemia and myeloma cells. FCY-302 selectively inhibited the proliferation of cancer cell lines, RPMI-8226, Jurkat and HL-60 by 8-, 9- and 13-fold more compared to normal Vero cells. FCY-302 decreased the anti-apoptotic Bcl-2 levels and increased pro-apoptotic Bax proteins in leukemia and myeloma cell lines. Results suggest that FCY-302 inhibited the proliferation of leukemia and myeloma cancer cells by altering key mitochondrial and antioxidant enzymes driving them to apoptosis.
Systematic Name: (E)-2-benzylidene-4-isopropyl-7-methyl-2,3-dihydro-1H-inden-1-one
Mol Wt: 276.38
Tags: Cancer, Leukemia, Apoptosis, small molecule, myeloma, BCL-2, RGNCY-0123, FCY-302, RPMI-8226, Jurkat, HL-60