RGNCY-0123 (FCY-302 Apoptosis inducer)

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FCY-302 is a novel inducer of apoptosis in leukemia and myeloma cells.  FCY-302 selectively inhibited the proliferation of cancer cell lines, RPMI-8226, Jurkat and HL-60 by 8-, 9- and 13-fold more compared to normal Vero cells.  FCY-302 decreased the anti-apoptotic Bcl-2 levels and increased pro-apoptotic Bax proteins in leukemia and myeloma cell lines.  Results suggest that FCY-302 inhibited the proliferation of leukemia and myeloma cancer cells by altering key mitochondrial and antioxidant enzymes driving them to apoptosis.  

Systematic Name:  (E)-2-benzylidene-4-isopropyl-7-methyl-2,3-dihydro-1H-inden-1-one

SMILES:  [H]/C(C1=CC=CC=C1)=C2CC(C(C(C)C)=CC=C3C)=C3C/2=O

Formula:  C20H20O

Mol Wt: 276.38

Tags: Cancer, Leukemia, Apoptosis, small molecule, myeloma, BCL-2, RGNCY-0123, FCY-302, RPMI-8226, Jurkat, HL-60