RGAB-001 (SgK269/PEAK1 Y1188)
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Phosphospecific polyclonal antibody against SgK269/PEAK1 Y1188.
SgK269 is a pseudokinase scaffold that plays a key role in determining the qualitative output of EGFR signalling, mediating a switch from pathways regulating proliferation/survival to those regulating cell morphology and invasion. It appears to play an important role in cell migration on fibronectin. SgK269 may also affect phosphorylation levels of of MAPK1/ERK and PXN. It also represents a breast cancer oncogene.
Croucher, David R., et al. "Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway." Cancer research 73.6 (2013): 1969-1980.
Phosphosite.org Ref.: 2204
Uniprot.org Ref.: Q9H792
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Tags: Cancer, Antibody, SgK269, ERK, proliferation, PEAK1, EGFR, breast cancer, RGAB-001, PEAK, Y1188, Invasion, MAPK1, MAPK, PXN, Breast, Pseudokinase, Phosphospecific, Polyclonal