RGNCY-0048 (PKC-9, PKC-zeta inhibitor )

IN STOCK!!  E-mail us at info@reagency.co if you are interested in this product.

PKC-9 is a 2-(6-phenyl-1H indazol-3-yl)-1H-benzo[d]imidazole derivative optimized to be a  potent and selective inhibitor of protein kinase c-zeta (PKC-ζ; 5.18nM). The analog displays good selectivity over other PKC isoforms (α, βII, γ, δ, ε, μ, θ, η and ι/λ) and CDK-2. The inhibition of PKC-ζ is proposed to be a potential drug target for immune and inflammatory diseases.

Systematic Name:  4-(3-(4-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazol-6-yl)aniline


Formula: C25H25N7

Mol Wt: 423.52

PMID:  19097791

Data Sheet


Interested in this reagent? E-mail us at info@reagency.co and let us know.

Tags: Kinase, inflammation, PKC-zeta, immunity, RGNCY-0048, PKC, PKC-9, PKC-z