RGNCY-0097 (M36 p32 inhibitor)
M36 is a unique pharmacophore of C1q and LyP-1 tumor homing peptide associating with p32. Mitochondrial protein p32 is a validated thearpaeutic target of cancer and is over-expressed in glioma. M36 binds directly to p32 and inhibits LyP-1 association with p32 in vitro. Furthermore, M36 effectively inhibits the growth of p32 over-expressed glioma cells and sensitises the cell to glucose depletion. M36 is worthy of further development as a potent and highly selective brain penetrant targeting mitochondrial p32.
Systematic Name: 1,1'-(propane-1,3-diyl)bis(3-(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)urea)
Mol Wt: 448.53
Tags: Small molecules, Cancer, glioma, Glioblastoma, M36, RGNCY-0097, LyP-1, SF188, U373, UW426, P-32