RGNCY-0118 (MC2494 pan SIRT inhibitor)

SOLD OUT!!  E-mail us at info@reagency.co if you are interested in this product.

MC249 is a pan Sirtuin (SIRT) inhibitor.  MC249 displays tumor-selective effects in vitro, in leukemic blasts ex vivo and in xenograft and allograft cancer models in vivo.  MC249 was shown to induce tumor-restricted acetylated RIP1/caspase-8-mediated apoptosis and inhibits tumor cell migration.  Importantly, MC249 has tumor-preventative activity by blocking 7,12-dimethylbenz(a)anthracene-induced mammary gland hyperproliferation in vivo.  MC249 is a promising candidate for cancer treatment and prevention.

Systematic Name: (E)-3-(4-(2-chlorobenzoyl)-1H-pyrrol-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide

SMILES: ClC1=C(C(C2=CNC(/C=C(C#N)/C(NC3=CC=CC4=C3C=CC=N4)=O)=C2)=O)C=


Formula: C24H15ClN4O2  

Mol Wt: 426.86

Tags: Cancer, Apoptosis, proliferation, migration, small molecule, Tumor, RGNCY-0118, MC249, SIRT