RGNCY-0118 (MC2494 pan SIRT inhibitor)
MC249 is a pan Sirtuin (SIRT) inhibitor. MC249 displays tumor-selective effects in vitro, in leukemic blasts ex vivo and in xenograft and allograft cancer models in vivo. MC249 was shown to induce tumor-restricted acetylated RIP1/caspase-8-mediated apoptosis and inhibits tumor cell migration. Importantly, MC249 has tumor-preventative activity by blocking 7,12-dimethylbenz(a)anthracene-induced mammary gland hyperproliferation in vivo. MC249 is a promising candidate for cancer treatment and prevention.
Systematic Name: (E)-3-(4-(2-chlorobenzoyl)-1H-pyrrol-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide
Mol Wt: 426.86
Tags: Cancer, Apoptosis, proliferation, migration, small molecule, Tumor, RGNCY-0118, MC249, SIRT